Publications

Publications

PANCAID publications

• Can our experience with surveillance for inherited pancreatic cancer help to identify early pancreatic cancer in the general population?

  J.-Matthias Löhr, Daniel Öhlund, Emma Söreskog, Emil Andersson, Miroslav Vujasinovic, Niklas Zethraeus, Malin Sund
  
  Abstract
  Screening of the general population for cancer is a matter of primary prevention reducing the burden of disease. Whilst this is successful for several cancers including breast, colon and prostate, the situation to screen and hence prevent pancreatic cancer is different. The organ is not as accessible to simple physical exam or biological samples (fecal or blood
  test). Neither exists a blood test such as PSA that is cost-effective. Reviewing the evidence from screening risk groups for pancreatic cancer, one must conclude that there is no rational at present to screen the general population, for a lack of appropriate tests.
  https://doi.org/10.1007/s10689-024-00363-6

Background Literature

• UEG position paper on pancreatic cancer. Bringing pancreatic cancer to the 21st century: Prevent, detect, and treat the disease earlier and better

  Patrick Michl, Matthias Löhr, John P. Neoptolemos, et al. (2021)
  
  Research on pancreatic cancer has being receiving little or minimal funds
  from European funding bodies. UEG is calling for public‐private partnerships that
  would effectively fund research on pancreatic cancer.
  Conclusion: This would increase our understanding of this disease and better
  treatment, through pan‐European efforts that take advantage of the strong academic European research
  https://doi.org/10.1002/ueg2.12123

• Liquid Biopsy: From Discovery to Clinical Application

  Catherine Alix-Panabières and, Klaus Pantel (2021)
  
  Over the past 10 years, circulating tumor cells (CTC) and circulating tumor DNA (ctDNA) have received enormous attention as new biomarkers and subjects of translational research. Although both biomarkers are already used in numerous clinical trials, their clinical utility is still under investigation with promising first results. Clinical applications include early cancer detection, improved cancer staging, early detection of relapse, real-time monitoring of therapeutic efficacy, and detection of therapeutic targets and resistance mechanisms. Here, we propose a conceptual framework of CTC and ctDNA assays and point out current challenges of CTC and ctDNA research, which might structure this dynamic field of translational cancer research. SIGNIFICANCE: The analysis of blood for CTCs or cell-free nucleic acids called "liquid biopsy" has opened new avenues for cancer diagnostics, including early detection of tumors, improved risk assessment and staging, as well as early detection of relapse and monitoring of tumor evolution in the context of cancer therapies.
  https://pubmed.ncbi.nlm.nih.gov/33811121/

• Pancreatic Cancer: A Review of Current Treatment and Novel Therapies

  Hordur Mar Kolbeinsson, Sreenivasa Chandana, G. Paul Wright & Mathew Chung (2023)
  
  The paper provides information on the current treatment and novel therapies for pancreatic cancer, including the use of surgery, systemic chemotherapy, genomic testing, and targeted therapies. It does not specifically mention what is known about pancreatic cancer in general.
  https://www.doi.org/10.1080/08941939.2022.2129884

• A comprehensive review of pancreatic cancer and its therapeutic challenges

  Shan Jiang, Johan Bourghardt Fagman, Yunyun Ma, et al. (2022)
  
  The paper provides information on the molecular mechanisms of pancreatic cancer, drug resistance, immune escaping mechanisms, and potential therapeutic approaches. It also mentions that surgery is currently the only potentially curative treatment for pancreatic cancer patients.
  https://www.doi.org/10.18632/aging.204310

• Pancreatic Cancer: A Review of Risk Factors, Diagnosis, and Treatment

  ZhiYu Zhao and Wei Liu (2020)
  
  Pancreatic cancer is a highly invasive malignant tumor that mainly affects men and older adults. It is also increasingly observed in young patients.
  https://www.doi.org/10.1177/1533033820962117